PLSCR4
Description
The PLSCR4 (phospholipid scramblase 4) is a protein-coding gene located on chromosome 3.
Phospholipid scramblase 4, also known as Ca2+-dependent phospholipid scramblase 4, is a protein encoded by the PLSCR4 gene in humans.
PLSCR4 mediates rapid, ATP-independent movement of phospholipids across the cell membrane in both directions when calcium ions bind to it. This movement disrupts the normal asymmetry of phospholipids in the cell membrane. PLSCR4 plays a key role in triggering fibrin clot formation, activating mast cells, and enabling the reticuloendothelial system to recognize and clear apoptotic and damaged cells.
PLSCR4 is also known as TRA1.
