PLS3
Description
The PLS3 (plastin 3) is a protein-coding gene located on chromosome X.
Plastin-3 is a highly conserved protein encoded by the PLS3 gene on the X chromosome. It belongs to the plastin family of actin-binding proteins, which are found in most tissues of higher eukaryotes. In humans, there are two ubiquitous plastin isoforms: L and T. Plastin 1 (Fimbrin) is a third isoform specifically expressed in the small intestine. The L isoform is found only in hemopoietic cell lineages, while the T isoform is present in all other normal cells with replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of T-plastin and L-plastin are 83% identical. Plastin-3 has a potential calcium-binding site near the N-terminus. Defects in PLS3 are linked to osteoporosis and bone fractures in humans and zebrafish.
Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.
PLS3 is also known as BMND18, DIH5, T-plastin.
