PLEKHO1
Description
The PLEKHO1 (pleckstrin homology domain containing O1) is a protein-coding gene located on chromosome 1.
Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene. PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1 and SMURF1.
PLEKHO1 plays a crucial role in regulating the actin cytoskeleton by interacting with actin capping protein (CP). It acts as an adapter, targeting CK2 to the plasma membrane, facilitating the phosphorylation of CP by CK2. PLEKHO1 also targets ATM to the plasma membrane. It inhibits tumor cell growth by suppressing AKT-mediated cell survival. Furthermore, it's involved in PI3K-regulated muscle differentiation, regulating AP-1 activity (a plasma membrane-bound AP-1 regulator that translocates to the nucleus), and promoting apoptosis induced by TNF. When bound to PKB, it inhibits its activity by decreasing PKB phosphorylation.
PLEKHO1 is also known as CKIP-1, CKIP1, JBP, OC120.
