PLD4

---

Description

The PLD4 (phospholipase D family member 4) is a protein-coding gene located on chromosome 14.

Phospholipase D family member 4 is an enzyme encoded by the PLD4 gene in humans. It is involved in various cellular processes, including the regulation of inflammatory responses and phagocytosis.

PLD4 is also known as C14orf175.

Associated Diseases

• endometrial cancer
• systemic lupus erythematosus
• autoimmune lymphoproliferative syndrome type 4
• immunodeficiency 72 with autoinflammation
• common variable immunodeficiency
• severe combined immunodeficiency due to LAT deficiency
• immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
• immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
• autoimmune lymphoproliferative syndrome
• immunodeficiency 105
• severe combined immunodeficiency due to DCLRE1C deficiency
• BENTA disease
• isolated agammaglobulinemia
• combined immunodeficiency due to ZAP70 deficiency
• autoimmune lymphoproliferative syndrome type 2A
• severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive