PLCG2 : phospholipase C gamma 2
Description
The PLCG2 (phospholipase C gamma 2) is a protein-coding gene located on chromosome 16.
The PLCG2 gene encodes phospholipase C gamma 2 (PLCγ2), an enzyme responsible for relaying signals from outside the cell to the inside. This signaling directs cellular functions, including growth, maturation, and movement. PLCγ2 is particularly crucial in immune cells like B cells, NK cells, and mast cells. It plays a key role in the immune response by enabling these cells to recognize and attack foreign invaders. When foreign invaders are detected, PLCγ2 triggers B cells to produce antibodies, which mark the invaders for destruction. It is also involved in NK cell-mediated destruction of invaders. PLCγ2 signaling in mast cells and other immune cells initiates inflammation, helping to clear infections or irritants. Mast cells also participate in allergic reactions.
PLCG2 is also known as APLAID, FCAS3, PLC-IV, PLC-gamma-2.
Associated Diseases
- Familial cold autoinflammatory syndrome 3
- Autoinflammation, antibody deficiency, and immune dysregulation, plcg2-associated
- PLCG2-associated antibody deficiency and immune dysregulation
