PLCB2

Description

The PLCB2 (phospholipase C beta 2) is a protein-coding gene located on chromosome 15.

PLCB2, encoded by the PLCB2 gene, is an enzyme that catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate into inositol 1,4,5-trisphosphate and diacylglycerol. This process, which requires calcium as a cofactor, is essential for intracellular signal transduction. The gene is activated by G-protein alpha subunits (alpha-q and alpha-11) as well as G-beta gamma subunits. PLCB2 interacts with MAP2K3 and TRPM7.

Phosphatidylinositol-specific phospholipase C enzymes, when activated, catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).

PLCB2 is also known as PLC-beta-2.

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