PLB1
Description
The PLB1 (phospholipase B1) is a protein-coding gene located on chromosome 2.
PLB1 is a calcium-independent membrane-associated phospholipase that breaks down phospholipids by removing both fatty acid chains attached to the glycerol backbone, exhibiting phospholipase B activity. It also has both phospholipase and lysophospholipase activities towards diacylphospholipids, preferentially cleaving sn-2 ester bonds. Additionally, it acts as a lipase towards glycerolipid substrates, hydrolyzing fatty acyl chains of diacylglycerols, preferentially at the sn-2 position, and of triacylglycerols with no positional selectivity. PLB1 might also hydrolyze long chain retinyl esters like retinyl palmitate. This enzyme may contribute to the digestion of dietary phospholipids, glycerolipids, and retinoids, facilitating lipid absorption at the brush border.
PLB1 is also known as PLB, PLB/LIP.
