PKN2
Description
The PKN2 (protein kinase N2) is a protein-coding gene located on chromosome 1.
Serine/threonine-protein kinase N2 is an enzyme that in humans and Strongylocentrotus purpuratus is encoded by the PKN2 gene.
PKN2, also known as PKN gamma, Protein kinase C-like 2, Protein-kinase C-related kinase 2, is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. PKN2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. It phosphorylates HDAC5, therefore leading to impair HDAC5 import. PKN2 is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. It is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. PKN2 stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. It regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. PKN2 inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). PKN2 is involved in the negative regulation of ciliogenesis.
PKN2 is also known as PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7.
