PKM
Description
The PKM (pyruvate kinase M1/2) is a protein-coding gene located on chromosome 15.
PKM or PKM may refer to:
PKM catalyzes the final step of glycolysis, converting phosphoenolpyruvate (PEP) to pyruvate while generating ATP. The balance between its active tetrameric and inactive dimeric forms regulates glucose usage, with the tetrameric form promoting ATP production and the dimeric form favoring biosynthetic processes. This dynamic equilibrium is essential for controlling glycolysis and is crucial for tumor cell growth and survival.
PKM is also known as CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58.
