PKD2L1
Description
The PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) is a protein-coding gene located on chromosome 10.
The PKD2L1 gene encodes Polycystic kidney disease 2-like 1 protein, also known as transient receptor potential polycystic 2 (TRPP2). This protein is part of the polycystin family and contains multiple transmembrane domains, functioning as a calcium-regulated nonselective cation channel. It is likely involved in cell-cell/matrix interactions and may have alternative splice variants. PKD2L1 has been shown to interact with TNNI3.
PKD2L1 is a pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to calcium ions. It also forms calcium-permeant ion channels with PKD1L1 in primary cilia, regulating cilium calcium concentration and influencing sonic hedgehog signaling and GLI2 transcription. Additionally, it forms a channel with PKD1L3, contributing to sour taste perception in gustatory cells. This channel is activated by low pH but opens only when the extracellular pH rises again. PKD2L1 may play a role in the perception of carbonation taste and water sensory perception through mechanisms involving salivary bicarbonate dilution and pH changes.
PKD2L1 is also known as PCL, PKD2L, PKDL, TRPP3.
