PITPNB
Description
The PITPNB (phosphatidylinositol transfer protein beta) is a protein-coding gene located on chromosome 22.
Phosphatidylinositol transfer protein beta isoform is a protein that in humans is encoded by the PITPNB gene. The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes.
PI-TP-beta catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). It also catalyzes the transfer of sphingomyelin (By similarity). PI-TP-beta is required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109).
PITPNB is also known as PI-TP-beta, PtdInsTP, VIB1B.
