PIP4K2B
Description
The PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta) is a protein-coding gene located on chromosome 17.
PIP4K2B is a human gene that encodes an enzyme called phosphatidylinositol-5-phosphate 4-kinase type-2 beta. This enzyme converts phosphatidylinositol 4-phosphate to phosphatidylinositol 4,5-bisphosphate, an important signaling molecule. PIP4K2B belongs to the phosphatidylinositol-4-phosphate 5-kinase family and interacts with the p55 TNF receptor. It has been shown to interact with TNFRSF1A and PIP4K2A, and may modulate the cellular location of PIP4K2A. The structure of PIP4K2B has been determined using X-ray crystallography.
PIP4K2B is involved in the production of phosphatidylinositol 4,5-bisphosphate (PIP2), a key signaling molecule. It prefers GTP over ATP as its energy source for this process, and its activity is directly related to the body's GTP levels. This GTP-sensing ability is essential for adjusting metabolism to changing conditions. PIP4K2B also plays a role in insulin signaling, acting to reduce insulin's effects by interacting with and inhibiting other enzymes involved in PIP2 production.
PIP4K2B is also known as PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB.
