PIM3
The PIM3 Gene: A Key Player in Cell Regulation
Description
The PIM3 gene, also known as Pim-3 proto-oncogene, serine/threonine kinase, is located on the short arm of human chromosome 6. It encodes a protein kinase that belongs to the PIM family of serine/threonine kinases. PIM3 is involved in various cellular processes, including cell cycle regulation, apoptosis, and cell survival.
Associated Diseases
Alterations in the PIM3 gene have been linked to several human diseases, including:
- Cancer: PIM3 overexpression has been observed in various types of cancer, including breast, lung, and colon cancers. It contributes to tumor growth, metastasis, and resistance to therapy.
- Immune disorders: PIM3 plays a role in immune cell function and has been implicated in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
- Cardiovascular diseases: PIM3 has been linked to abnormal heart function and may contribute to the development of heart failure.
Did you Know ?
In a study of breast cancer patients, high levels of PIM3 protein were associated with a significantly shorter survival time compared to patients with low PIM3 levels. This suggests that PIM3 overexpression is a potential prognostic marker for cancer patients.
