PILRA
Description
The PILRA (paired immunoglobin like type 2 receptor alpha) is a protein-coding gene located on chromosome 7.
PILRA, or Paired Immunoglobin-Like Type 2 Receptor Alpha, is a protein encoded by the PILRA gene in humans. It plays a crucial role in regulating cell signaling pathways by acting as an inhibitory receptor. PILRA's function is mediated by its interaction with phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2, which it recruits through its ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) domains. These phosphatases dephosphorylate tyrosine residues, effectively inhibiting signal transduction. PILRA's inhibitory function balances the activating role of its counterpart, PILRbeta. Both PILRA and PILRbeta are located on chromosome 7 and are involved in controlling cell signaling through a delicate balance of inhibitory and activating processes. Interestingly, PILRA has been shown to interact with numerous proteins, unlike PILRbeta, which only interacts with one known ligand. Alternative splicing gives rise to different isoforms of PILRA, each with a unique structure and function.
PILRA is also known as FDF03.
