PI4K2B
Description
The PI4K2B (phosphatidylinositol 4-kinase type 2 beta) is a protein-coding gene located on chromosome 4.
Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene.
PI4K2B contributes to the overall PI4-kinase activity of the cell alongside PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB). This activity is particularly important in plasma membrane, endosomal, and Golgi compartments. PI4K2B catalyzes the phosphorylation of phosphatidylinositol (PI) to PI4P, a critical step in producing phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 serves as a precursor for the second messenger inositol 1,4,5-trisphosphate (InsP3). PI4K2B contributes to InsP3 production in stimulated cells and likely plays a role in regulating vesicular trafficking.
PI4K2B is also known as PI4KIIB, PIK42B.
