PHF2
Description
The PHF2 (PHD finger protein 2) is a protein-coding gene located on chromosome 9.
PHF2 is a protein encoded by the PHF2 gene in humans. It contains a PHD finger domain, which is a zinc finger-like motif involved in gene regulation. PHF2 is thought to be a transcriptional regulator that influences chromatin structure and gene expression.
PHF2 is a lysine demethylase that removes methyl groups from both histones and non-histone proteins. It is inactive on its own but becomes active after phosphorylation by protein kinase A (PKA). PHF2 forms a complex with ARID5B, which it also demethylates. This demethylation allows the PHF2-ARID5B complex to bind to gene promoters, where PHF2 removes dimethylated lysine 9 from histone H3 (H3K9me2), leading to gene activation. The PHF2-ARID5B complex acts as a coactivator of HNF4A in the liver. PHF2 also binds to trimethylated lysine 4 of histone H3 (H3K4me3) at ribosomal DNA (rDNA) promoters and promotes rDNA expression. In macrophages, PHF2 helps activate genes targeted by toll-like receptor 4 (TLR4) by removing trimethylated lysine 20 from histone H4 (H4K20me3) at the gene promoters.
PHF2 is also known as CENP-35, GRC5, JHDM1E, KDM7C.
