PHF19
Description
The PHF19 (PHD finger protein 19) is a protein-coding gene located on chromosome 9.
PHF19, also known as Polycomb-like protein 3, is a Polycomb group (PcG) protein that specifically binds to histone H3 trimethylated at Lys-36 (H3K36me3). It recruits the PRC2 complex, enhancing its H3K27me3 methylation activity. PHF19 likely plays a role in the transition from an active to a repressed state in embryonic stem cells. It binds to H3K36me3, a marker for transcriptional activation, and recruits histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex, resulting in H3K27me3 methylation and silencing. PHF19 also recruits the PRC2 complex to CpG islands, contributing to embryonic stem cell self-renewal. Additionally, PHF19 binds to histone H3 dimethylated at Lys-36 (H3K36me2). Isoform 1 and isoform 2 of PHF19 inhibit transcription from an HSV-tk promoter.
PHF19 is also known as MTF2L1, PCL3, TDRD19B.
