PHF13
Description
The PHF13 (PHD finger protein 13) is a protein-coding gene located on chromosome 1.
PHF13 is a protein that modulates chromatin structure and DNA damage response. It interacts with various proteins involved in these processes, including H3K4me3, TRIM28, and SETDB1. PHF13 is essential for normal chromosome condensation and separation during mitosis and plays a role in testicular stem-cell differentiation.
PHF13, also known as Survival time-associated PHD finger protein in ovarian cancer 1, plays a crucial role in regulating chromatin structure and DNA damage response. It binds to chromatin marked with H3K4me3, promoting DNA condensation by recruiting corepressors like TRIM28 and SETDB1, a H3K9 methyltransferase. This interaction leads to increased levels and activity of H3K9 methyltransferases, ultimately enhancing H3K9 trimethylation. PHF13 is essential for proper chromosome condensation and separation during mitosis. Moreover, it is crucial for the differentiation of testicular stem cells and sustained spermatogenesis.
PHF13 is also known as PHF5, SPOC1.
