PHF10
Description
The PHF10 (PHD finger protein 10) is a protein-coding gene located on chromosome 6.
PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene. This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28.
PHF10, also known as BRG1-associated factor 45a or XAP135, is involved in regulating transcription activity by remodeling chromatin. It is a component of the neural progenitors-specific chromatin remodeling complex (npBAF complex), which is essential for the proliferation of neural progenitors. During neural development, a switch occurs from the npBAF complex to a neuron-specific complex (nBAF), as neurons exit the cell cycle and differentiate. This switch involves the exchange of subunits within the complex, with PHF10/BAF45A being replaced by DPF1/BAF45B or DPF3/BAF45C. The npBAF complex is crucial for the self-renewal and proliferation of neural stem cells, while the nBAF complex, along with CREST, plays a role in regulating genes essential for dendrite growth.
PHF10 is also known as BAF45A, SMARCG4, XAP135.
