PFKFB4
Description
The PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) is a protein-coding gene located on chromosome 3.
PFKFB4, encoded by the PFKFB4 gene, is a bifunctional enzyme that regulates the concentration of fructose 2,6-bisphosphate. This molecule acts as an activator of phosphofructokinase, a key enzyme in glycolysis. PFKFB4 plays a critical role in balancing energy production and preventing the accumulation of free radicals, which can lead to cell death. Research suggests that PFKFB4 could be a suitable drug target for cancer treatment.
PFKFB4 catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, a key regulator of glycolysis.
PFKFB4 is also known as -.
Associated Diseases
- endometrial cancer
- breast cancer
- nonpapillary renal cell carcinoma
- cancer
- glioblastoma
- female infertility due to oocyte meiotic arrest
