PFKFB1

Description

The PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) is a protein-coding gene located on chromosome X.

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

PFKFB1 is also known as F6PK, HL2K, PFRX.

Associated Diseases

• endometrial cancer
• colorectal cancer
• cancer
• breast cancer
• COVID-19
• urinary bladder carcinoma
• precursor B-cell acute lymphoblastic leukemia
• Miyoshi myopathy
• maturity-onset diabetes of the young type 2
• gastric cancer
• Chagas disease