PFDN6

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Description

The PFDN6 (prefoldin subunit 6) is a protein-coding gene located on chromosome 6.

Prefoldin subunit 6 is a protein that in humans is encoded by the PFDN6 gene.

Prefoldin subunit 6 specifically binds to cytosolic chaperonin (c-CPN) and delivers target proteins to it. It also interacts with nascent polypeptide chains and facilitates their proper folding in a cellular environment where numerous pathways compete for misfolded proteins.

PFDN6 is also known as H2-KE2, HKE2, KE-2, PFD6.

Associated Diseases

• hemoglobin D disease
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• hemoglobin E disease
• dominant beta-thalassemia
• delta-beta-thalassemia
• hemoglobin E-beta-thalassemia syndrome
• alpha-thalassemia-myelodysplastic syndrome
• hemoglobin C-beta-thalassemia syndrome
• hemoglobin H disease
• monosomy 7 myelodysplasia and leukemia syndrome 1
• microcytic anemia with liver iron overload
• overhydrated hereditary stomatocytosis
• hereditary elliptocytosis