PEA15
Description
The PEA15 (proliferation and apoptosis adaptor protein 15) is a protein-coding gene located on chromosome 1.
PEA-15, encoded by the PEA15 gene, is a death effector domain (DED)-containing protein primarily found in the central nervous system, specifically in astrocytes. It promotes autophagy in glioma cells through a JNK-dependent mechanism. PEA-15 interacts with proteins such as Caspase 8, FADD, MAPK1, Phospholipase D1, and RPS6KA3.
PEA15 plays a role in regulating cell signaling and apoptosis. It counteracts Ras-mediated suppression of integrin activation and modulates the ERK MAP kinase pathway. PEA15 prevents RPS6KA3 activity by holding it within the cytoplasm. It inhibits caspase-8 activation and apoptosis triggered by TNFRSF6 and TNFRSF1A. Additionally, PEA15 regulates glucose transport by controlling the levels of SLC2A1 glucose transporters on the cell membrane and the insulin-dependent movement of SLC2A4 from the cell interior to the surface.
PEA15 is also known as HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15.
Associated Diseases
- glioblastoma
- type 2 diabetes mellitus
- breast cancer
- cancer
- schizophrenia
- ovarian cancer
- Mobius syndrome
- malignant glioma
