PDXP
Description
The PDXP (pyridoxal phosphatase) is a protein-coding gene located on chromosome 22.
PDXP (Pyridoxal phosphate phosphatase) plays a vital role in vitamin B6 metabolism by acting as a phosphatase for pyridoxal phosphate (PLP), pyridoxine 5'-phosphate (PNP), and pyridoxamine 5'-phosphate (PMP), with a preference for PLP over PNP and PMP. Additionally, PDXP functions as a protein serine phosphatase, specifically targeting 'Ser-3' within proteins of the actin-depolymerizing factor (ADF)/cofilin family, such as CFL1 and DSTN. This dephosphorylation regulates cofilin-dependent actin cytoskeleton reorganization, crucial for normal mitotic progression and cytokinesis. PDXP does not dephosphorylate phosphothreonines in LIMK1 or peptides containing phosphotyrosine.
PDXP is also known as CIN, PLP, dJ37E16.5.
