PDS5B
Description
The PDS5B (PDS5 cohesin associated factor B) is a protein-coding gene located on chromosome 13.
PDS5B (Sister chromatid cohesion protein PDS5 homolog B) is a protein encoded by the PDS5B gene in humans. It functions as a regulatory subunit of the Cohesin complex, which mediates sister chromatid cohesion, homologous recombination, and DNA looping. The core cohesin complex consists of SMC3, SMC1, RAD21, and either SA1 or SA2. PDS5B associates with WAPL to stimulate the release of cohesin from DNA, but during DNA replication, it promotes acetylation of SMC3 by ESCO1 and ESCO2.
PDS5B regulates sister chromatid cohesion during mitosis, potentially stabilizing the cohesin complex's association with chromatin. It may link sister chromatid cohesion to DNA replication during mitosis. Cohesion ensures accurate chromosome partitioning in both meiosis and mitosis and is crucial for DNA repair. PDS5B plays a role in androgen-induced proliferative arrest in prostate cells.
PDS5B is also known as APRIN, AS3, CG008.
