PDS5A
Description
The PDS5A (PDS5 cohesin associated factor A) is a protein-coding gene located on chromosome 4.
PDS5A, or Sister chromatid cohesion protein PDS5 homolog A, is a protein encoded by the PDS5A gene in humans.
PDS5A is a probable regulator of sister chromatid cohesion in mitosis, potentially stabilizing the association of the cohesin complex with chromatin. It may link sister chromatid cohesion during mitosis to DNA replication. Cohesion is crucial for accurate chromosome partitioning in both meiotic and mitotic cells and plays a critical role in DNA repair.
PDS5A is also known as PIG54, SCC-112, SCC112.
Associated Diseases
- endometrial cancer
- urinary bladder cancer
- Cornelia de Lange syndrome
- Ulbright-Hodes syndrome
- Holzgreve-Wagner-Rehder syndrome
- congenital absence of upper arm and forearm with hand present
- ventricular septal defect 1
- autosomal recessive spondylocostal dysostosis
- isolated Pierre-Robin syndrome
- atrioventricular septal defect 5
- diaphanospondylodysostosis
