PDHA2

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Description

The PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2) is a protein-coding gene located on chromosome 4.

The pyruvate dehydrogenase complex, which contains PDHA2, is responsible for converting pyruvate to acetyl-CoA and CO(2). This process links the glycolytic pathway to the tricarboxylic acid cycle, a crucial energy-producing pathway in the cell.

PDHA2 is also known as PDHAL, SPGF70.

Associated Diseases

• Male infertility with azoospermia or oligozoospermia due to single gene mutation
• Spermatogenic failure 70