PDGFD
Description
The PDGFD (platelet derived growth factor D) is a protein-coding gene located on chromosome 11.
Platelet-derived growth factor D (PDGF-D) is a protein encoded by the PDGFD gene in humans. It belongs to the platelet-derived growth factor family, known for their mitogenic activity on cells of mesenchymal origin. PDGF-D is characterized by a core motif of eight cysteines, seven of which are shared by other family members. Unlike other family members, it only forms homodimers and possesses an unusual N-terminal CUB domain. Two splice variants have been identified for this gene.
PDGF-D plays a crucial role in regulating embryonic development, cell proliferation, migration, survival, and chemotaxis. It acts as a potent mitogen for mesenchymal cells and is essential for wound healing. PDGF-D promotes macrophage recruitment, interstitial pressure elevation, and blood vessel maturation during angiogenesis. Notably, it can trigger events leading to mesangial proliferative glomerulonephritis, characterized by monocyte and macrophage influx and extracellular matrix production.
PDGFD is also known as IEGF, MSTP036, SCDGF-B, SCDGFB.
