PDGFB : platelet derived growth factor subunit B

Description

The PDGFB (platelet derived growth factor subunit B) is a protein-coding gene located on chromosome 22.

The PDGFB gene provides instructions for making a protein called platelet-derived growth factor (PDGF) subunit B. This protein is involved in many important cellular processes, including cell growth and division, maturation, and movement. PDGF-B is made as a precursor protein that must be processed before it can function. The precursor form combines with another PDGFB protein or a similar protein called PDGFA to form a structure called a dimer. After the dimer is formed, the precursor proteins are cut at specific locations, forming the active PDGF proteins, PDGF-BB and PDGF-AB. The active PDGF-BB or PDGF-AB protein binds to a PDGF receptor, which initiates a series of signals within the cell. These signals activate many pathways that are important in cell proliferation, differentiation, and movement.

PDGF-B is a growth factor that plays a critical role in various biological processes, including:

Embryonic development: It contributes to the regulation of development during the embryonic stage.
Cell proliferation: It promotes the growth and division of cells, particularly those of mesenchymal origin.
Cell migration: It facilitates the movement of cells, aiding in processes like wound healing.
Cell survival: It promotes the survival of cells, preventing their death.
Chemotaxis: It guides the movement of cells in response to chemical signals.

PDGF-B is a potent mitogen for cells of mesenchymal origin. It is essential for the normal proliferation and recruitment of pericytes (cells that wrap around blood vessels) and vascular smooth muscle cells in various tissues, including the central nervous system, skin, lung, heart, and placenta. PDGF-B is also crucial for normal blood vessel development and the formation of kidney glomeruli (filtering units in the kidney). Its role in wound healing makes it essential for tissue repair.

The signaling activity of PDGF-B is modulated by the formation of heterodimers with PDGFA.

PDGFB is also known as IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing