PDGFA
Description
The PDGFA (platelet derived growth factor subunit A) is a protein-coding gene located on chromosome 7.
PDGFA, encoded by the PDGFA gene, is a protein belonging to the platelet-derived growth factor family. This family consists of mitogenic factors that stimulate the growth of mesenchymal cells and are characterized by a motif of eight cysteines. PDGFA can exist as a homodimer or a heterodimer with the PDGFB polypeptide, linked by disulfide bonds. Studies using knockout mice have demonstrated cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells, leading to embryonic or postnatal lethality. Two splice variants have been identified for this gene.
PDGFA is a growth factor crucial for embryonic development, regulating processes like cell proliferation, migration, survival, and chemotaxis. It acts as a potent mitogen for mesenchymal cells and is essential for proper lung development (alveolar septum formation), gastrointestinal development, Leydig cell maturation and spermatogenesis. PDGFA also plays a critical role in the development and myelination of oligodendrocytes in the spinal cord and cerebellum. Additionally, it contributes significantly to wound healing. Its signaling pathways are modulated by interactions with PDGFB, forming heterodimers.
PDGFA is also known as PDGF-A, PDGF1.
