PDE4DIP
Description
The PDE4DIP (phosphodiesterase 4D interacting protein) is a protein-coding gene located on chromosome 1.
PDE4DIP, also known as Myomegalin or Cardiomyopathy-associated protein 2, is a protein encoded by the PDE4DIP gene in humans. It is involved in the formation of microtubules from the centrosome, a cellular structure crucial for cell division and organization. The protein is named for its high expression in sarcomeres, the contractile units of muscle fibers, and its large size, consisting of 2,324 amino acids. It was first described in 2000. PDE4DIP is predominantly composed of alpha-helix and coiled-coil structures, sharing domains with other microtubule-associated proteins. It exists in multiple isoforms, with at least two characterized: CM-MMG and EB-MMG. CM-MMG binds to the centrosome with γ-tubulin in an AKAP9-dependent manner and to the Golgi apparatus, while EB-MMG binds to MAPRE1 at the Golgi apparatus, enhancing its effects on microtubule growth. PDE4DIP, specifically the CM-MMG isoform, is a paralogue of CDK5RAP2. Depletion of PDE4DIP in cells does not lead to decreased γ-tubulin or CDK5RAP2 levels, unlike CDK5RAP2 depletion, and does not appear to affect mitosis through spindle anchoring and orientation defects, suggesting that CDK5RAP2 can partially compensate for the absence of PDE4DIP.
The PDE4DIP gene encodes a protein that serves as an anchor, binding to and concentrating components of the cAMP-dependent signaling pathway at the Golgi apparatus and/or centrosomes.
PDE4DIP is also known as CMYA2, MMGL.
