PDE12
Description
The PDE12 (phosphodiesterase 12) is a protein-coding gene located on chromosome 3.
PDE12 is a human gene that encodes the enzyme 2',5'-phosphodiesterase 12, also known as mitochondrial deadenylase. This enzyme plays a role in the regulation of the 2-5A system, an important pathway for antiviral and antitumor responses. PDE12 acts by breaking down 2-5A, a signaling molecule that activates antiviral and antitumor responses. By breaking down 2-5A, PDE12 reduces the body's ability to fight off these threats.
PDE12, also known as mitochondrial deadenylase, cleaves the 2',5'-phosphodiester bond in 5'-triphosphorylated oligoadenylates (2-5A). It degrades 2-5A to AMP and ATP. PDE12 also cleaves the 3',5'-phosphodiester bond of oligoadenylates, acting as a negative regulator of the 2-5A system, which is involved in antiviral and antitumor responses induced by interferons (IFNs). Suppression of PDE12 increases 2-5A levels and reduces viral replication in cells.
PDE12 is also known as 2'-PDE, 2-PDE.
Associated Diseases
- type 1 diabetes mellitus
- osteoarthritis
- type 2 diabetes mellitus
- Nager acrofacial dysostosis
- pulmonary hypertension
- glioblastoma
- COVID-19
