PDCD4
The PDCD4 Gene: Unraveling Its Role in Health and Disease
Description
Gene Name: Programmed Cell Death 4 (PDCD4)
Location: Chromosome 10q24.32
Function: The PDCD4 gene encodes a protein known as Programmed Cell Death Protein 4. This protein plays a crucial role in regulating cell growth, proliferation, and apoptosis (programmed cell death).
Associated Diseases
Cancer: PDCD4 mutations have been implicated in the development of various types of cancer, including lung cancer, breast cancer, and colorectal cancer. In cancer cells, PDCD4 deficiency can lead to uncontrolled cell growth and proliferation.
Neurological Disorders: PDCD4 has also been associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Alterations in PDCD4 expression have been observed in the brains of patients with these conditions.
Immune System Disorders: PDCD4 is involved in regulating the immune response. Dysregulation of PDCD4 can contribute to autoimmune diseases such as lupus and rheumatoid arthritis.
Did you Know ?
- A study found that PDCD4 mutations are present in approximately 20% of lung cancer cases, making it one of the most frequently mutated genes in this type of cancer.
