PDCD2
Description
The PDCD2 (programmed cell death 2) is a protein-coding gene located on chromosome 6.
PDCD2 is a protein encoded by the PDCD2 gene. It is found in various tissues and resides in the nucleus. Its rat homolog, Rp8, is expressed in developing thymocytes and is linked to programmed cell death. The human PDCD2 gene's expression is suppressed by BCL6, a protein crucial for lymph node development, suggesting BCL6 controls apoptosis through its influence on PDCD2. The PDCD2 gene is located close to the TBP gene on chromosome 6. Multiple protein variations are produced from this gene. PDCD2 interacts with Host cell factor C1 and Parkin (ligase).
PDCD2 is also known as RP8, ZMYND7.
Associated Diseases
- chromosome 22q11.2 microduplication syndrome
- jaw-winking syndrome
- ptosis, hereditary congenital, 1
- syndromic orbital border hypoplasia
- short tarsus-absence of lower eyelashes syndrome
- gastrointestinal stromal tumor
- cancer
- type 1 diabetes mellitus
- T-cell non-Hodgkin lymphoma
- Bloom syndrome
