PDCD1LG2

Description

The PDCD1LG2 (programmed cell death 1 ligand 2) is a protein-coding gene located on chromosome 9.

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1).

== Structure ==

PD-L2 is a cell surface receptor belonging to the B7 protein family. It consists of both an immunoglobulin-like variable domain and an immunoglobulin-like constant domain in the extracellular region, a transmembrane domain, and a cytoplasmic domain. PD-L2 shares considerable sequence homology with other B7 proteins, but it does not contain the putative binding sequence for CD28/CTLA4, namely SQDXXXELY or XXXYXXRT. The crystal structure of murine PD-L2 bound to murine PD-1 has been determined. as well as the structure of the hPD-L2/mutant hPD-1 complex.

== Expression ==

=== Profile === PD-L2 is primarily expressed on professional antigen presenting cells including dendritic cells (DCs) and macrophages. Others have shown PD-L2 expression in certain T helper cell subsets and cytotoxic T cells.

PDCD1LG2 is also known as B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2.

Associated Diseases

WES Whole Exome Sequencing