PCP4
Description
The PCP4 (Purkinje cell protein 4) is a protein-coding gene located on chromosome 21.
PCP4 (Purkinje cell protein 4) is a protein encoded by the PCP4 gene in humans. It is also known as PEP-19 and is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). PCP4 is abundant in Purkinje cells of the cerebellum and plays a crucial role in synaptic plasticity. PCP4 knockout mice exhibit impaired locomotor learning and altered synaptic plasticity in cerebellar Purkinje neurons. PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is thought to influence the activity of CaM-dependent enzymes, particularly CaM kinase II (CaMK-II).
PCP4 regulates the activity of calmodulin by modulating its calcium-binding properties. This regulation impacts various cellular processes controlled by calmodulin, including neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways. (PubMed:19106096, PubMed:21491429, PubMed:23204517, PubMed:27876793)
PCP4 is also known as PEP-19.
