PCP2
Description
The PCP2 (Purkinje cell protein 2) is a protein-coding gene located on chromosome 19.
PCP site 2 is a distinct binding site with high affinity for phencyclidine (PCP), a drug known to block NMDA receptors. This site is separate from the traditional PCP binding site on NMDA receptors and the main binding sites on serotonin, dopamine, and norepinephrine transporters. PCP site 2 is associated with the inhibition of monoamine reuptake and may serve as a regulatory site for these transporters. RTI-4793-14 (HBMP) is a compound that preferentially binds to PCP site 2 over the classic PCP site and inhibits monoamine reuptake with moderate potency. However, unlike PCP, RTI-4793-14 has minimal effects on NMDA receptors. While initially believed to be solely related to PCP site 2, further studies revealed that RTI-4793-14 also binds to the dopamine transporter with significant affinity. The interactions of RTI-4793-14 with serotonin and norepinephrine transporters are yet to be fully characterized but could contribute to its monoamine reuptake inhibition, potentially providing an alternative explanation to the PCP site 2 hypothesis.
PCP2 is also known as GPSM4, PCD5.
