PCM1
Description
The PCM1 (pericentriolar material 1) is a protein-coding gene located on chromosome 8.
PCM1 is a protein encoded by the PCM1 gene in humans. It plays a crucial role in cell division, associating with the centrosome complex and microtubules during the cell cycle. It is found in centriolar satellites and electron-dense granules. Depletion of PCM1 using siRNA, overexpression of PCM1 deletion mutants, or microinjection of PCM1 antibodies disrupts the radial organization of microtubules, suggesting its importance for cell division. PCM1 has four known transcripts, the longest of which has 39 exons.
PCM1 is essential for centrosome assembly and function, playing a crucial role in the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. It anchors microtubules to the centrosome. PCM1 is also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. It recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites.
PCM1 is also known as PTC4, RET/PCM-1.
