PCBP4
Description
The PCBP4 (poly(rC) binding protein 4) is a protein-coding gene located on chromosome 3.
The PCBP4 gene encodes a protein belonging to the KH domain protein subfamily, also known as alpha-CPs. These proteins bind to RNA, particularly C-rich pyrimidine regions. PCBP4 plays a crucial role in post-transcriptional processes and is found in the cytoplasm. Interestingly, PCBP4 lacks the nuclear localization signals present in other members of the subfamily. The p53 tumor suppressor induces the expression of PCBP4, which in turn can suppress cell proliferation by inducing apoptosis and cell cycle arrest in the G(2)-M phase. Multiple alternatively spliced transcript variants have been identified for PCBP4, but the complete structure of only some variants has been determined.
PCBP4 binds preferentially to oligo dC, a type of single-stranded nucleic acid.
PCBP4 is also known as CBP, LIP4, MCG10.
Associated Diseases
- endometrial cancer
- low grade glioma
- lung cancer
- BAP1-related tumor predisposition syndrome
- Li-Fraumeni syndrome
- autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis
- retinal degeneration
- cancer
