PBDC1
Description
The PBDC1 (polysaccharide biosynthesis domain containing 1) is a protein-coding gene located on chromosome X.
PBDC1, also known as CXorf26 or MGC874, is a well-conserved human gene located on the plus strand of the short arm of the X chromosome. The gene spans the genomic region from bases 75,393,420-75,397,740 on the X chromosome (Xq13.3). PBDC1's exact function is not fully understood, but the polysaccharide biosynthesis domain that makes up a large part of the protein, along with its yeast homolog YPL225, provides clues to its potential roles.
Possible Functions
Based on the protein's interactions, PBDC1 is likely involved in the processes involving RNA polymerase II, ubiquitination, and ribosomes. This connection stems from the observed interactions of both PBDC1 and its yeast homolog YPL225W with numerous ubiquitinated proteins and the transcriptional enzyme RNA polymerase II. For example, the ubiquitination and subsequent degradation of the 26S proteasome plays a critical role in regulating transcription in eukaryotic cells. The yeast protein RPN11, which interacts with YPL225W, has a human homolog that is a metalloprotease component of the 26S proteasome, responsible for degrading proteins targeted for destruction by the ubiquitin pathway. However, these functions don't seem directly related to polysaccharide biosynthesis, suggesting a possible role for the domain in protein secondary structure or phosphorylation.
Further research is needed to clarify PBDC1's precise role in these key cellular processes. Experiments such as inhibiting RNA polymerase II and observing subsequent gene expression of PBDC1 could shed light on its function. A complete knockout of YPL225W in yeast using methods like RNAi could also provide valuable insights.
Gene Information
PBDC1 is located on the plus strand of the short arm of the X chromosome, specifically at locus Xq13.3. It covers a genomic region from bases 75,393,420-75,397,740. The primary mRNA transcript for PBDC1 contains 1214 base pairs, and its protein product, UPF0368, is composed of 233 amino acids with a predicted mass of 26,057 Da.
PBDC1 is also known as CXorf26.
