PASK
Description
The PASK (PAS domain containing serine/threonine kinase) is a protein-coding gene located on chromosome 2.
PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene. PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli.
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}
PASK is also known as PASKIN, STK37.
Associated Diseases
- prostate cancer
- hyperinsulinemic hypoglycemia, familial, 2
- exercise-induced hyperinsulinism
- hypoinsulinemic hypoglycemia and body hemihypertrophy
- hyperinsulinemic hypoglycemia, familial, 1
- islet cell adenomatosis
