PARP16
Description
The PARP16 (poly(ADP-ribose) polymerase family member 16) is a protein-coding gene located on chromosome 15.
PARP16, or Poly (ADP-ribose) polymerase family, member 16, is a human protein encoded by the PARP16 gene.
PARP16 is an intracellular mono-ADP-ribosyltransferase that plays a role in protein translation and the unfolded protein response (UPR). It inhibits protein translation by mono-ADP-ribosylating ribosomal subunits, such as RPL14 and RPS6, which inhibits polysome assembly and mRNA loading. This process is promoted by NMNAT2. PARP16 also participates in the UPR by activating EIF2AK3 and ERN1, two key UPR effectors. Additionally, PARP16 may modify karyopherin KPNB1, a nuclear import factor. Unlike other mono-ADP-ribosyltransferases, PARP16 may not modify proteins on arginine or cysteine residues.
PARP16 is also known as ARTD15, C15orf30, pART15.
