PARP10
Description
The PARP10 (poly(ADP-ribose) polymerase family member 10) is a protein-coding gene located on chromosome 8.
PARP10 is an enzyme that helps control gene activity by adding ADP-ribose molecules to histones, which are proteins that package DNA. This process alters the structure of chromatin, the complex of DNA and proteins that makes up chromosomes, and affects gene expression.
PARP10 is an ADP-ribosyltransferase that adds a single ADP-ribose molecule (mono-ADP-ribosylation) to glutamate and aspartate residues on target proteins. Unlike PARP1 and PARP2, PARP10 cannot add multiple ADP-ribose molecules (poly-ADP-ribosylation). PARP10 modifies GSK3B, inhibiting its kinase activity. PARP10 is involved in translesion DNA synthesis, a process that allows DNA replication to continue even when DNA is damaged. PARP10 interacts with PCNA, a protein involved in DNA replication, during translesion DNA synthesis.
PARP10 is also known as ARTD10.
