PARD3
Description
The PARD3 (par-3 family cell polarity regulator) is a protein-coding gene located on chromosome 10.
Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]
PARD3 has been shown to interact with:
JAM2, JAM3, PRKCI, and PVRL3.
PARD3, also known as PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, CTCL tumor antigen se2-5, or PAR3-alpha, is an adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). It plays a central role in the formation of epithelial tight junctions (PubMed:27925688). PARD3 targets the phosphatase PTEN to cell junctions (By similarity). PARD3 is also involved in Schwann cell peripheral myelination (By similarity). The association of PARD3 with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). PARD3 is required for the establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}
PARD3 is also known as ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2.
