PAN3
Description
The PAN3 (poly(A) specific ribonuclease subunit PAN3) is a protein-coding gene located on chromosome 13.
PAN3 poly(A) specific ribonuclease subunit is a protein that in humans is encoded by the PAN3 gene.
PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA, and this activity is stimulated by poly(A)-binding protein (PABP). Following PAN deadenylation, the shortened mRNA tails are rapidly degraded by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms: exosome-mediated 3'-5' exonucleolytic degradation or deadenylation-dependent mRNA decapping followed by 5'-3' exonucleolytic degradation by XRN1. PAN3 regulates PAN activity by recruiting the catalytic subunit PAN2 to mRNA via its interactions with RNA and PABP, and to miRNA targets via its interactions with GW182 family proteins.
PAN3 is also known as -.
Associated Diseases
- hemoglobin D disease
- dominant beta-thalassemia
- hemoglobin E disease
- hemoglobin C-beta-thalassemia syndrome
