PAIP2
Description
The PAIP2 (poly(A) binding protein interacting protein 2) is a protein-coding gene located on chromosome 5.
PAIP2 is a protein encoded by the PAIP2 gene in humans. It has been shown to interact with PABPC1.
PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated through its interaction with PABPC1. PAIP2 displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. The association of PAIP2 with PABPC1 disrupts the cytoplasmic poly(A) RNP structure organization.
PAIP2 is also known as PAIP-2, PAIP2A.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- congenital bilateral absence of vas deferens
- spermatogenic failures 50
- spermatogenic failure 61
- spermatogenic failure 74
- spermatogenic failure 73
- spermatogenic failure 63
- spermatogenic failure 26
- spermatogenic failure 31
- spermatogenic failure 25
- spermatogenic failure 52
- spermatogenic failure 23
- spermatogenic failure 5
- spermatogenic failure 48
- congenital bilateral aplasia of vas deferens from CFTR mutation
- spermatogenic failure 20
- spermatogenic failure 29
- spermatogenic failure 1
