PAFAH1B3
Description
The PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3) is a protein-coding gene located on chromosome 19.
Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene. PAFAH1B3 has been shown to interact with PAFAH1B1 and LNX1.
The PAFAH1B3 gene encodes the alpha1 subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)). This enzyme is a heterotetramer that catalyzes the hydrolysis of the acetyl group at the sn-2 position of PAF and its analogs, modulating the action of PAF. The activity and substrate specificity of PAF-AH (I) are influenced by its subunit composition. PAFAH1B3 forms both homodimers (alpha1/alpha1) and heterodimers with the PAFAH1B2 gene product (alpha1/alpha2), which exhibit enhanced hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) compared to PAF but limited activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). PAFAH1B3 is crucial during brain development.
PAFAH1B3 is also known as PAFAHG.
