PADI2
Description
The PADI2 (peptidyl arginine deiminase 2) is a protein-coding gene located on chromosome 1.
The PADI2 gene encodes protein-arginine deiminase type-2, an enzyme that catalyzes the post-translational deimination of proteins. This enzyme converts arginine residues into citrullines in the presence of calcium ions. PADI2 is the most widely expressed member of the peptidyl arginine deiminase family and has distinct substrate specificities. Known substrates include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. PADI2 is thought to play a role in neurodegenerative disorders such as Alzheimer's disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. The PADI2 gene exists in a cluster with four other paralogous genes.
PADI2 is also known as PAD-H19, PAD2, PDI2.
Associated Diseases
- breast cancer
- post-transplant lymphoproliferative disease
- retinoblastoma
- isolated asymptomatic elevation of creatine phosphokinase
- C1 inhibitor deficiency
- plasma fibronectin deficiency
- COVID-19
