PABPC4
Description
The PABPC4 (poly(A) binding protein cytoplasmic 4) is a protein-coding gene located on chromosome 1.
PABPC4 is a protein encoded by the PABPC4 gene in humans. It belongs to the poly(A)-binding protein (PABP) family and binds to the poly(A) tail of most eukaryotic mRNAs. PABPC4 was discovered as an activation-induced T-cell mRNA encoding a protein, with its levels increasing significantly in activated T cells. This protein contains four RNA-binding domains and a proline-rich C terminus, primarily localized to the cytoplasm. It is suggested that PABPC4 might be important for regulating the stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1, expressed on thrombin-activated rabbit platelets. It may be involved in regulating protein translation in platelets and megakaryocytes or participate in the binding or stabilization of polyadenylates in platelet dense granules. PABPC4 has been shown to interact with PHLDA1.
PABPC4 binds to the poly(A) tail of mRNA, playing a role in cytoplasmic mRNA metabolism. It likely binds to other cytoplasmic RNA sequences beyond just poly(A).
PABPC4 is also known as APP-1, APP1, PABP4, iPABP.
