OSR1
Description
The OSR1 (odd-skipped related transcription factor 1) is a protein-coding gene located on chromosome 2.
OSR1 (Odd-skipped-related 1) is a transcription factor encoded by the OSR1 gene in humans. It is crucial for the normal development of vital organs like kidneys. OSR1, along with its close relative OSR2, contributes to the formation of various body parts, including the kidneys and heart.
OSR1 is a zinc-finger protein with three C2H2 zinc finger domains. It shares a high degree of similarity with OSR2, particularly in its zinc finger domains. This protein belongs to the Odd-skipped class of transcription factors, known for their roles in regulating gene expression during development.
During early embryonic development (around day 7.5 in mice), OSR1 expression is observed in cells destined to become the intermediate mesoderm. This expression pattern shifts and becomes more concentrated in the developing kidneys by day 9.5.
OSR1 is also known as ODD.
